Sceletium tortuosum, also known as Kanna, Channa, or Kougoed (meaning “something to chew on” in Afrikaans), is a succulent plant native to South Africa. For centuries, the San and Khoikhoi peoples have revered Sceletium as a sacred plant, using it ceremonially and medicinally to enhance mood, reduce fear, and cultivate social connection. Traditionally, it was chewed, smoked, or made into teas and tinctures. Today, it is increasingly recognized worldwide for its potential to support mental and emotional wellbeing.

The traditional use of Sceletium dates back to pre-colonial times, with references as early as the 17th century. The Khoisan communities of the Klein Karoo and Namaqualand used fermented Sceletium during trance dances and communal ceremonies, where it helped calm the nervous system, promote open-heartedness, and heighten spiritual awareness. The plant was so culturally significant that it was often traded for cattle and other goods.

Notably, Sceletium’s name is linked to the Eland, a sacred trance animal in Bushmen cosmology, often depicted in rock art as a symbol of fertility, rainmaking, and spiritual potency. This connection speaks volumes about the plant’s energetic and cultural importance.

In recent decades, Sceletium has re-emerged in the spotlight as a potential natural alternative to pharmaceutical antidepressants and anxiolytics. As the world grapples with rising levels of stress, burnout, and emotional disconnection, more people are turning to ancient plant medicines for support.

Clinical and anecdotal evidence suggests that Sceletium may support:

• Mild to moderate depression
• Anxiety and social phobias
• ADHD, by improving focus and reducing restlessness
• PTSD and trauma integration
• Seasonal Affective Disorder (SAD)
• Emotional tension associated with menopause or hormonal imbalance
• Addiction recovery, by easing withdrawal symptoms and cravings

Sceletium contains several active alkaloids, including mesembrine, mesembrenone, and mesembrenol. These compounds interact with the brain in a variety of ways:

• Selective Serotonin Reuptake Inhibition (SSRI): Mesembrine blocks the reuptake of serotonin, allowing for more of this feel-good neurotransmitter to be available in the brain — similar to pharmaceutical SSRIs but without the common side effects.
• Serotonin Releasing Agent (SRA): Sceletium not only blocks reuptake but actively promotes the release of serotonin.
• PDE4 Inhibition: Mesembrenone inhibits phosphodiesterase-4, an enzyme associated with inflammation, cognitive dysfunction, and depression. This dual mechanism supports neuroprotection, enhanced cognition, and mood regulation.
• CB1 Receptor Modulation: Sceletium may also interact with endocannabinoid receptors, which influence mood, appetite, and pain perception (source).

Together, these actions make Sceletium a rare and powerful herbal ally.

Social and Spiritual Connection

• Social Ease: Reduces social phobia and improves verbal fluidity
• Heart-Opening: Promotes emotional vulnerability and deeper intimacy
• Meditation and Yoga: Enhances presence, body awareness, and breath coordination
• Trance and Visionary Use: At higher doses, Sceletium may induce mild empathogenic and visionary states, especially when combined with ceremony or other herbs

Sceletium is available in various forms: capsules, powders, tinctures, teas, and extracts. It may be taken:

• Sublingually (under the tongue) for fast absorption
• Orally, in capsule form
• Smoked, traditionally in ceremony
• Topically, in certain compounded blends

Recommended Microdosing Protocol:

• Take 1 capsule in the morning for 2 days, then skip 1 day, and repeat
• Adjust dosage based on individual sensitivity and strength (Light, Medium, Strong)

Always start low and go slow, especially with concentrated extracts.

• Do not combine with SSRIs, SNRIs, or other psychiatric medications

• Avoid during pregnancy or breastfeeding

• Consult a health professional if treating clinical depression or anxiety

1. What is Sceletium tortuosum and how does it work in the body?

Sceletium tortuosum, also known as Kanna, is a South African succulent that supports mood regulation by interacting with serotonin and dopamine systems. It acts as both a serotonin releasing agent (SRA) and a natural SSRI, while also inhibiting PDE4 — a process that enhances emotional resilience and mental clarity.

2. Can Sceletium help with anxiety and depression naturally?

Yes, Sceletium is widely used as a natural alternative to pharmaceutical antidepressants and anti-anxiety medications. Its active alkaloids help calm the nervous system, reduce emotional overwhelm, and uplift mood without causing dependency or harsh side effects.

3. Is Sceletium safe to use daily or for microdosing?

Sceletium is generally safe for daily use in microdoses, especially when fermented. Many people follow a protocol of 1 capsule in the morning for two days, followed by one day off. However, it should not be combined with SSRIs or psychiatric medications unless under medical supervision.

4. What’s the difference between fermented Sceletium and standard extract?

Fermented Sceletium has a higher concentration of active alkaloids like mesembrine, making it more bioavailable and effective. Traditional Khoisan fermentation also improves absorption and reduces digestive discomfort, making it the preferred option for long-term use.

5. Who should avoid taking Sceletium supplements?

Individuals taking pharmaceutical antidepressants (SSRIs/SNRIs), antipsychotics, or MAOIs should not use Sceletium unless advised by a healthcare provider. It’s also not recommended during pregnancy or breastfeeding due to limited research in these groups.